Intratumoral androgen biosynthesis associated with 3β-hydroxysteroid dehydrogenase 1 promotes resistance to radiotherapy in prostate cancer.

doi:10.1172/JCI165718

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Article

Intratumoral androgen biosynthesis associated with 3β-hydroxysteroid dehydrogenase 1 promotes resistance to radiotherapy in prostate cancer.

The Journal of clinical investigation - 15 Nov 2023

Ganguly Shinjini, Lone Zaeem, Muskara Andrew, Imamura Jarrell, Hardaway Aimalie, Patel Mona, Berk Mike, Smile Timothy D, Davicioni Elai, Stephans Kevin L, Ciezki Jay, Weight Christopher J, Gupta Shilpa, Reddy Chandana A, Tendulkar Rahul D, Chakraborty Abhishek A, Klein Eric A, Sharifi Nima, Mian Omar Y

Abstract excerpt

Half of all men with advanced prostate cancer (PCa) inherit at least 1 copy of an adrenal-permissive HSD3B1 (1245C) allele, which increases levels of 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) and promotes intracellular androgen biosynthesis. Germline inheritance of the adrenally permissive allele confers worse outcomes in men with advanced PCa. We investigated whether HSD3B1 (1245C) drives resistance to combined...

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Identifiers

PMID: 37966114
DOI: 10.1172/JCI165718
PMCID: PMC10645386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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