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Article

Adrenal-Permissive Germline HSD3B1 Allele and Prostate Cancer Outcomes.

JAMA network open - 4 Mar 2024

McKay Rana R, Nelson Tyler J, Pagadala Meghana S, Teerlink Craig C, Gao Anthony, Bryant Alex K, Agiri Fatai Y, Guram Kripa, Thompson Reid F, Pridgen Kathryn M, Seibert Tyler M, Lee Kyung Min, Carter Hannah, Lynch Julie A, Hauger Richard L, Rose Brent S

Abstract excerpt

Importance: The adrenal androgen-metabolizing 3β-hydroxysteroid dehydrogenase-1 enzyme, encoded by the HSD3B1 gene, catalyzes the rate-limiting step necessary for synthesizing nontesticular testosterone and dihydrotestosterone production. The common adrenal-permissive HSD3B1(1245C) allele is responsible for encoding the 3β-HSD1 protein with decreased susceptibility to degradation resulting in higher extragonadal...

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Identifiers

PMID: 38506808
DOI: 10.1001/jamanetworkopen.2024.2976
PMCID: PMC10955379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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