Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

13 Nov 2023

Abstract excerpt

Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the causative agent of Chagas disease. However, for reasons that are unknown, treatment failures are common. When we examined parasites that survived benznidazole treatment in mice using highly sensitive in vivo and ex vivo bioluminescence imaging, we found that recrudescence is not due to persistence of parasites in a specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parasitic Infections and Diagnostics
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37956215
DOI: 10.1371/journal.ppat.1011627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in micePMID 37956215Read ↗

Intracellular DNA replication and differentiation of <i>Trypanosoma cruzi</i> is asynchronous within individual host cells <i>in vivo</i> at all stages of infectionSemantic proximity Read ↗

The developmental hierarchy and scarcity of replicative slender trypanosomes in blood challenges their role in infection maintenanceSemantic proximity Read ↗

<i>In vivo</i> analysis of <i>Trypanosoma cruzi</i> persistence foci at single cell resolutionSemantic proximity Read ↗

In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell ResolutionSemantic proximity Read ↗

Transcriptomic and proteomic analysis of quiescent epimastigotes as a resource for investigating <i>Trypanosoma cruzi</i> persistenceSemantic proximity Read ↗

Multi-drug tolerance in <i>Leishmania</i> persister-like cellsSemantic proximity Read ↗

Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruziSemantic proximity Read ↗

Molecular Mechanisms of Persistence in Protozoan ParasitesSemantic proximity Read ↗

Active Transcriptome Remodeling and Epigenetic Adaptations Underlie Persistence in <i>Leishmania</i> parasitesSemantic proximity Read ↗

Bioluminescence imaging of chronic <scp> <i>T</i> </scp> <i>rypanosoma cruzi</i> infections reveals tissue‐specific parasite dynamics and heart disease in the absence of locally persistent infectionSemantic proximity Read ↗

Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas diseaseSemantic proximity Read ↗

Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.