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Article

Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Dec 1995

Nirdé P, Larroque C, Barnabé C

Abstract excerpt

In vitro benznidazole resistance was induced in cloned T. cruzi epimastigotes using a continuous drug pressure protocol. Stocks were selected according to their previous genetic characterization by multilocus enzyme electrophoresis. All the resistant clones were able to grow in long term cultivation in the presence of at least 50 microM benznidazole, which is the drug plasma level during chemotherapy in man. The...

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PMID: 8745639

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