Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes.

Article

Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Dec 1995

Nirdé P, Larroque C, Barnabé C

Abstract excerpt

In vitro benznidazole resistance was induced in cloned T. cruzi epimastigotes using a continuous drug pressure protocol. Stocks were selected according to their previous genetic characterization by multilocus enzyme electrophoresis. All the resistant clones were able to grow in long term cultivat...

Topics

Animals
Cell Division
Dose-Response Relationship, Drug
Drug Resistance, Microbial
Nitroimidazoles
Phenotype
Trypanocidal Agents
Trypanosoma cruzi

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