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Article

TWIST1 and TSG6 are coordinately regulated and function as potency biomarkers in human MSCs

10 Nov 2023

Abstract excerpt

Mesenchymal stem/stromal cells (MSCs) have been evaluated in >1500 clinical trials, but outcomes remain suboptimal because of knowledge gaps in quality attributes that confer potency. We show that TWIST1 directly represses TSG6 expression that TWIST1 and TSG6 are inversely correlated across bone marrow–derived MSC (BM-MSC) donor cohorts and predict interdonor differences in their proangiogenic, anti-inflammatory,...

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PMID: 37948519
DOI: 10.1126/sciadv.adi2387

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