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Responders vs. non-responders to mesenchymal stromal cells in knee osteoarthritis patients: mechanistic correlates of donor cell attributes and putative patient features

2025-07-20

Abstract excerpt

<h4>SUMMARY</h4> Mesenchymal stromal cell (MSC) injection has afforded heterogenous outcomes in knee osteoarthritis (KOA). Herein, a framework that dually correlates KOA patient responsiveness to baseline autologous bone m arrow-derived MSC(M) donor batch attributes and baseline clinical and biomarker features is provided. Using clinical trial data, we demonstrated that MSC(M) with increased immunomodulatory pot...

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Identifiers and source

Literature Corpus work
8158a943-012a-5de6-bca7-2c40e178f6d9
DOI
10.1101/2025.07.17.665028
Open publication

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Responders vs. non-responders to mesenchymal stromal cells in knee osteoarthritis patients: mechanistic correlates of donor cell attributes and putative patient featuresDOI 10.1101/2025.07.17.665028
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