Article

Combined computational and experimental analysis confirm donor-dependent optimization of critical processing parameters for improving mesenchymal stromal cell potency and expansion attributes

2026-07-06

Abstract excerpt

Mesenchymal Stromal Cells (MSC) face several heterogeneity challenges hindering clinical and commercial success. Employing a multiple response model, interplay between donor heterogeneity, and critical processing parameters (CPPs), effects on MSC potency and cell expansion attributes were investigated through computed composite attribute scores. Twelve unique CPP combinations were tested in thirteen m arrow-deriv...

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Literature Corpus work: ca8f82b6-ffdb-5e41-a551-b4ccce7808c4
DOI: 10.64898/2026.07.03.735619

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