Article

Tumour genotype shapes blood biomarker expression for use in pancreatic cancer detection and diagnosis

2025-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Typically diagnosed late, when systemic metastasis has already occurred, pancreatic ductal adenocarcinoma (PDAC) has one of the worst 5-year survival rates of any cancer type. For many patients with advanced disease, current chemotherapy regimens offer only modest benefit despite significant toxicity and surgical resection, the only treatment option with curative potential, is not possible. Ther...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b060bade-911f-5349-befe-6aff8f444e8f
DOI: 10.1101/2025.08.15.670486

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumour genotype shapes blood biomarker expression for use in pancreatic cancer detection and diagnosisDOI 10.1101/2025.08.15.670486Read

Deconstructing Pancreatic Cancer Using Next Generation-Omic Technologies–From Discovery to Knowledge-Guided Platforms for Better Patient ManagementSemantic proximity Read

Understanding pancreatic cancer genomesSemantic proximity Read

Clinical utility of molecular subtyping of pancreatic cancerSemantic proximity Read

Next-Generation Sequencing in Pancreatic CancerSemantic proximity Read

Next generation sequencing of pancreatic ductal adenocarcinoma: right or wrong?Semantic proximity Read

Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancerSemantic proximity Read

Genomics in Primary and Secondary Prevention of Pancreatic Cancer.Semantic proximity Read

Multi-omic characterization reveals a distinct molecular landscape in young-onset pancreatic cancerSemantic proximity Read

Early detection of pancreatic cancer: Where are we now and where are we going?Semantic proximity Read

Hereditary Pancreatic Cancer: Advances in Genetic Testing, Early Detection Strategies, and Personalized ManagementSemantic proximity Read

Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinomaSemantic proximity Read

Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancerSemantic proximity Read