Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways

15 Jun 2019

Abstract excerpt

Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical relevance. Epidemiological data suggest that congenital IGF1 deficiency confers protection against the development of malignancies. This 'experiment of nature' reflects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Growth Hormone and Insulin-like Growth Factors
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31208077
DOI: 10.3390/cells8060596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection PathwaysPMID 31208077Read ↗

Identification of signaling pathways associated with cancer protection in Laron syndromeSemantic proximity Read ↗

Congenital IGF-1 deficiency protects from cancer: lessons from Laron syndromeSemantic proximity Read ↗

Laron Syndrome Research Paves the Way for New Insights in Oncological InvestigationSemantic proximity Read ↗

Clinical and Molecular Features of Laron Syndrome, A Genetic Disorder Protecting from Cancer.Semantic proximity Read ↗

Insulin-like growth factors and aging: lessons from Laron syndromeSemantic proximity Read ↗

IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome.Semantic proximity Read ↗

Congenital IGF1 deficiency tends to confer protection against post-natal development of malignanciesSemantic proximity Read ↗

Hallmarks of cancer: The insulin-like growth factors perspectiveSemantic proximity Read ↗

A New Homozygous IGF1R Variant Defines a Clinically Recognizable Incomplete Dominant form of SHORT Syndrome.Semantic proximity Read ↗

Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary reportSemantic proximity Read ↗

Growth hormone and cancerSemantic proximity Read ↗

Disorders of IGFs and IGF-1R signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.