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Article

Differences in Cascade Genetic Testing Among Families With Hereditary Cancer Risk.

JAMA network open - 1 Jun 2026

Namey Elia, Horton Carolyn, Dudley Beth, Carraway Cassidy, Komala Timothy, Milliard Carrie, Namey Tara, Karloski Eve, Brand Randall

Abstract excerpt

Importance: Performing germline genetic testing of family members following the identification of an individual with a pathogenic variant in a cancer predisposition gene, a process known as cascade testing, is a critical step in maximizing the preventive benefit of genetic testing for hereditary cancer. Objective: To determine how often family members undergo cascade testing and to evaluate demographic,...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42377955
DOI: 10.1001/jamanetworkopen.2026.21242
PMCID: PMC13320652

Genes

ATM
BRCA1
BRCA2
CHEK2
PALB2
EPCAM
MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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