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Article

PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via spindle assembly checkpoint reactivation.

The Journal of clinical investigation - 2 Jan 2024

Wang Jian, Chen Yuke, Li Shiwei, Liu Wanchang, Zhou Xiao Albert, Luo Yefei, Xu Zhanzhan, Xiong Yundong, Cheng Kaiqi, Ruan Mingjian, Yu Wei, Li Xiaoman, Wang Weibin, Wang Jiadong

Abstract excerpt

Mutations in the BRCA2 tumor suppressor gene have been associated with an increased risk of developing prostate cancer. One of the paradoxes concerning BRCA2 is the fact that its inactivation affects genetic stability and is deleterious for cellular and organismal survival, while BRCA2-mutated cancer cells adapt to this detriment and malignantly proliferate. Therapeutic strategies for tumors arising from BRCA2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37934606
DOI: 10.1172/JCI172137
PMCID: PMC10760972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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