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Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors

14 Jan 2014

Abstract excerpt

The spindle checkpoint is essential to ensure proper chromosome segregation and thereby maintain genomic stability. Mitotic arrest deficiency 2 (Mad2), a critical component of the spindle checkpoint, is overexpressed in many cancer cells. Thus, we hypothesized that Mad2 overexpression could specifically make cancer cells susceptible to death by inducing a synthetic dosage lethality defect. Because the spindle...

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PMID: 24425774
DOI: 10.1073/pnas.1315588111

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