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Evolutionary "Crowdsourcing": Alignment of Fitness Landscapes Allows for Cross-species Adaptation of a Horizontally Transferred Gene.

Molecular biology and evolution - 3 Nov 2023

Kosterlitz Olivia, Grassi Nathan, Werner Bailey, McGee Ryan Seamus, Top Eva M, Kerr Benjamin

Abstract excerpt

Genes that undergo horizontal gene transfer (HGT) evolve in different genomic backgrounds. Despite the ubiquity of cross-species HGT, the effects of switching hosts on gene evolution remains understudied. Here, we present a framework to examine the evolutionary consequences of host-switching and apply this framework to an antibiotic resistance gene commonly found on conjugative plasmids. Specifically, we...

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PMID: 37931146
DOI: 10.1093/molbev/msad237
PMCID: PMC10657783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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