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Shear stress in the intervillous space promotes syncytial formation of iPS cells-derived trophoblasts

31 Oct 2023

Abstract excerpt

The intervillous space of human placenta is filled with maternal blood, and villous trophoblasts are constantly exposed to the shear stress generated by maternal blood pressure and flow throughout the entire gestation period. However, the effects of shear stress on villous trophoblasts and their biological significance remain unknown. Here, using our recently established naïve human pluripotent stem cells-derived...

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PMID: 37930227
DOI: 10.1093/biolre/ioad143

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