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Trophoblast organoids with physiological polarity model placental structure and function

7 Sept 2023

Abstract excerpt

Human trophoblast organoids (TOs) are a three-dimensional ex vivo culture model that can be used to study various aspects of placental development, physiology and pathology. However, standard culturing of TOs does not recapitulate the cellular orientation of chorionic villi in vivo given that the multi-nucleated syncytiotrophoblast (STB) develops largely within the inner facing surfaces of these organoids...

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PMID: 37676312
DOI: 10.1242/jcs.261528

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