Article
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease.
Molecular brain - 3 Nov 2023
Valdes Phoebe, Henry Kenneth W, Fitzgerald Michael Q, Muralidharan Koushik, Caldwell Andrew B, Ramachandran Srinivasan, Goldstein Lawrence S B, Mobley William C, Galasko Douglas R, Subramaniam Shankar
Abstract excerpt
Non-familial Alzheimer's disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer's disease (EOAD) and constitutes ~ 5-6% of all AD cases (Mendez et al. in Continuum 25:34-51, 2019). While EOAD exhibits the same clinicopathological changes such as amyloid plaques, neurofibrillary tangles (NFTs), brain atrophy, and cognitive decline (Sirkis et al. in Mol Psychiatry 27:2674-88,...
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