Article
Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma.
The Journal of biological chemistry - 1 Dec 2023
Baqai Usman, Kurimchak Alison M, Trachtenberg Isabella V, Purwin Timothy J, Haj Jelan I, Han Anna, Luo Kristine, Pachon Nikole Fandino, Jeon Angela, Chua Vivian, Davies Michael A, Gutkind J Silvio, Benovic Jeffrey L, Duncan James S, Aplin Andrew E
Abstract excerpt
Most uveal melanoma cases harbor activating mutations in either GNAQ or GNA11. Despite activation of the mitogen-activated protein kinase (MAPK) signaling pathway downstream of Gαq/11, there are no effective targeted kinase therapies for metastatic uveal melanoma. The human genome encodes numerous understudied kinases, also called the "dark kinome". Identifying additional kinases regulated by Gαq/11 may uncover...
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