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Interplay between the DNA damage response and the life cycle of DNA tumor viruses

31 Oct 2023

Abstract excerpt

Approximately 20 % of human cancers are associated with virus infection. DNA tumor viruses can induce tumor formation in host cells by disrupting the cell's DNA replication and repair mechanisms. Specifically, these viruses interfere with the host cell's DNA damage response (DDR), which is a complex network of signaling pathways that is essential for maintaining the integrity of the genome. DNA tumor viruses can...

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PMID: 37918513
DOI: 10.1016/j.tvr.2023.200272

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