The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson’s disease

Abstract excerpt

Parkinson’s disease (PD) is characterized by the pathologic aggregation and prion-like propagation of α-synuclein (α-syn). Emerging evidence shows that fungal infections increase the incidence of PD. However, the molecular mechanisms by which fungi promote the onset of PD are poorly understood. Here, we show that nasal infection with Saccharomyces cerevisiae ( S. cerevisiae ) in α-syn A53T transgenic mice...

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