Article
The prion hypothesis: from biological anomaly to basic regulatory mechanism.
Nature reviews. Molecular cell biology - 1 Dec 2010
Tuite Mick F, Serio Tricia R
Abstract excerpt
Prions are unusual proteinaceous infectious agents that are typically associated with a class of fatal degenerative diseases of the mammalian brain. However, the discovery of fungal prions, which are not associated with disease, suggests that we must now consider the effect of these factors on basic cellular physiology in a different light. Fungal prions are epigenetic determinants that can alter a range of...
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