Description of the genetic variants identified in a cohort of patients diagnosed with localized anal squamous cell carcinoma and treated with panitumumab.

doi:10.1038/s41598-021-86966-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Description of the genetic variants identified in a cohort of patients diagnosed with localized anal squamous cell carcinoma and treated with panitumumab.

Scientific reports - 1 Apr 2021

Trilla-Fuertes Lucía, Gámez-Pozo Angelo, Maurel Joan, Garcia-Carbonero Rocio, Capdevila Jaume, G-Pastrián Laura, Mendiola Marta, Peña Cristina, López-Vacas Rocío, Cuatrecasas Miriam, García-Alfonso Pilar, Ramos-Ruiz Ricardo, Llorens Carlos, Ghanem Ismael, Conill Carles, Heredia-Soto Victoria, Campos-Barros Ángel, Fresno Vara Juan Ángel, Feliu Jaime

Abstract excerpt

Squamous cell carcinoma is the most frequent histologic type of anal carcinoma. The standard of care since the 1970s has been a combination of 5-fluorouracil, mitomycin C, and radiotherapy. This treatment is very effective in T1/T2 tumors (achieving complete regression in 80-90% of tumors). However, in T3/T4 tumors, the 3-year relapse free survival rate is only 50%. The VITAL trial aimed to assess the efficacy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Immunological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Combined Chemotherapy Protocols

Share to Anus Neoplasms

Share to Clinical Trials as Topic

Share to Combined Modality Therapy

Share to Molecular Targeted Therapy

Share to Neoplasm Metastasis

Share to Panitumumab

Source

Open in PubMed Open full text

Identifiers

PMID: 33795829
DOI: 10.1038/s41598-021-86966-w
PMCID: PMC8016846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Description of the genetic variants identified in a cohort of patients diagnosed with localized anal squamous cell carcinoma and treated with panitumumab.PMID 33795829Read ↗

Pathogenic alterations in PIK3CA and KMT2C are frequent and independent prognostic factors in anal squamous cell carcinoma treated with salvage abdominoperineal resection.Semantic proximity Read ↗

Comprehensive characterization of the mutational landscape in localized anal squamous cell carcinomaSemantic proximity Read ↗

Comprehensive Genomic Profiling of Advanced Anal Adenocarcinoma in Japan.Semantic proximity Read ↗

Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes.Semantic proximity Read ↗

Molecular characterization of squamous cell carcinoma of the anal canalSemantic proximity Read ↗

Genetic characteristics and targeted treatments of primary bladder and urachal adenocarcinomas: a systematic review with pooled descriptive genomic analyses.Semantic proximity Read ↗

Genetic Analysis in Anal and Cervical Cancer: Exploratory Findings About Radioresistance in the ProfiLER Database.Semantic proximity Read ↗

Genomic profiles of Indonesian colorectal cancer patientsSemantic proximity Read ↗

Comprehensive Genomic Profiling of Metastatic Squamous Cell Carcinoma of the Anal Canal.Semantic proximity Read ↗

Whole genome sequencing in oesophageal adenocarcinoma unmasks potential precision therapies.Semantic proximity Read ↗

Genomic profiles of Indonesian colorectal cancer patients.Semantic proximity Read ↗

Molecular and genomic characterisation of a panel of human anal cancer cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.