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Article

DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype-phenotype prediction.

Genome medicine - 31 Oct 2023

Chandrashekar Pramod Bharadwaj, Alatkar Sayali, Wang Jiebiao, Hoffman Gabriel E, He Chenfeng, Jin Ting, Khullar Saniya, Bendl Jaroslav, Fullard John F, Roussos Panos, Wang Daifeng

Abstract excerpt

BACKGROUND: Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive. With emerging multimodal data for these mechanisms, machine learning methods can be applied for phenotype prediction at different scales, but due to the black-box nature of machine learning, integrating these modalities and...

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PMID: 37904203
DOI: 10.1186/s13073-023-01248-6
PMCID: PMC10617196

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