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Article

Decoding the genomic symphony: unravelling brain disorders through data integration and machine learning.

Molecular psychiatry - 1 Dec 2025

Bracher-Smith Matthew, Escott-Price Valentina

Abstract excerpt

Machine learning (ML) is revolutionising our ability to decode the complex genetic architectures of brain disorders. In this review we examine the strengths and limitations of ML methods, highlighting their applications in genetic prediction, patient stratification, and the modelling of genetic interactions. We explore how ML can augment polygenic risk scores (PRS) through advanced techniques and how integrating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41176580
DOI: 10.1038/s41380-025-03330-4
PMCID: PMC12602323

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