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The PfAP2‐G2 transcription factor is a critical regulator of gametocyte maturation

25 Dec 2020

Abstract excerpt

Differentiation from asexual blood stages to mature sexual gametocytes is required for the transmission of malaria parasites. Here, we report that the ApiAP2 transcription factor, PfAP2-G2 (PF3D7_1408200) plays a critical role in the maturation of Plasmodium falciparum gametocytes. PfAP2-G2 binds to the promoters of a wide array of genes that are expressed at many stages of the parasite life cycle. Interestingly,...

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PMID: 33368818
DOI: 10.1111/mmi.14676

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