PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages

Abstract excerpt

Malaria pathogenicity results from the parasite’s ability to invade, multiply within and then egress from the host red blood cell (RBC). Infected RBCs are remodeled, expressing antigenic variant proteins (such as PfEMP1, coded by the var gene family) for immune evasion and survival. These processes require the concerted actions of many proteins, but the molecular regulation is poorly understood. We have character...

Topics

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• Complement system in diseases
• Drug Transport and Resistance Mechanisms
• HIV Research and Treatment
• Invertebrate Immune Response Mechanisms
• Malaria Research and Control
• Mosquito-borne diseases and control
• Trypanosoma species research and implications
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

bb144d96-a679-5fb1-ac41-e945ad884299

DOI

10.1101/2023.05.23.541898