Article
Transcriptomic and phenotype analysis revealed the role of rpoS in stress resistance and virulence of a novel ST3355 ESBL-producing hypervirulent Klebsiella pneumoniae isolate.
Frontiers in cellular and infection microbiology - 1 Jan 2023
Zhou Yi, Cheng Yue, Ma Tianyou, Wang Jun, Li Shaoru, Wang Jingdan, Han Lei, Hou Xinyao, Ma Xinxin, Jiang Sijin, Li Pu, Lv Jia, Han Bei, Da Rong
Abstract excerpt
Introduction: An extended-spectrum beta-lactamase (ESBL)-hypervirulent Klebsiella pneumoniae (HvKP) strain HKE9 was isolated from the blood in an outpatient. Methods: The effect of the global regulatory factor RpoS on antimicrobial resistance, pathogenicity, and environmental adaptability was elucidated. Results: HKE9 is a novel ST3355 (K20/O2a) hypervirulent strain with a positive string test and resistant to...
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