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TargetGene: a comprehensive database of cell-type-specific target genes for genetic variants.

Nucleic acids research - 5 Jan 2024

Lin Shiqi, Wu Song, Zhao Wei, Fang Zhanjie, Kang Hongen, Liu Xinxuan, Pan Siyu, Yu Fudong, Bao Yiming, Jia Peilin

Abstract excerpt

Annotating genetic variants to their target genes is of great importance in unraveling the causal variants and genetic mechanisms that underlie complex diseases. However, disease-associated genetic variants are often located in non-coding regions and manifest context-specific effects, making it challenging to accurately identify the target genes and regulatory mechanisms. Here, we present TargetGene...

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PMID: 37870478
DOI: 10.1093/nar/gkad901
PMCID: PMC10767789

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