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Exploring homologous recombination repair and base excision repair pathway genes for possible diagnostic markers in hematologic malignancies.

Molecular genetics and genomics : MGG - 1 Nov 2023

Abbasi Sumaira Fida, Mahjabeen Ishrat, Parveen Neelam, Qamar Imama, Haq Maria Fazal Ul, Shafique Rabia, Saeed Nadia, Ashraf Nida Sarosh, Kayani Mahmood Akhtar

Abstract excerpt

Hematologic malignancies (HMs) are a collection of malignant transformations, originating from the cells in the bone marrow and lymphoid organs. HMs comprise three main types; leukemia, lymphoma, and multiple myeloma. Globally, HMS accounts for approximately 10% of newly diagnosed cancer. DNA repair pathways defend the cells from recurrent DNA damage. Defective DNA repair mechanisms such as homologous...

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PMID: 37861816
DOI: 10.1007/s00438-023-02078-2

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