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Controversies in oncology: are genomic tests quantifying homologous recombination repair deficiency (HRD) useful for treatment decision making?

1 Jan 2019

Abstract excerpt

Mechanisms that protect DNA are crucial to preserve the genome integrity from injuries produced by environmental agents or those spontaneously generated during DNA metabolism.1 DNA single-strand breaks (SSBs) are repaired by mismatch repair (MMR), base excision repair (BER) and nucleotide excision repair (NER).1 Non-homologous end joining (NHEJ) or homologous recombination repair (HRR) processes double-strand...

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PMID: 31231558
DOI: 10.1136/esmoopen-2018-000480

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