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Histone acetylation by SAGA Complex but not by NuA4 Complex is Required for filamentation programme in <i>Candida albicans</i>

2025-06-27

Abstract excerpt

Candida albicans , a major human fungal pathogen undergoes filamentation from yeast to hyphal state under filamentation-inducing conditions. Gcn5 and Esa1 are key histone H3 and H4 acetyltransferases, respectively, encoded by the budding yeast and other eukaryotes. While Gcn5, a subunit of the SAGA complex, and Esa1, a subunit of the NuA4 complex are critical for C. albicans virulence and hyphal induction, how th...

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Literature Corpus work
fdca97c5-1995-53c4-b17a-af2347148556
DOI
10.1101/2025.06.24.661151
Open publication

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