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New Insights into the Pathology of Podocyte Loss

3 Sept 2013

Abstract excerpt

Podocytes represent an essential component of the kidney's glomerular filtration barrier. They stay attached to the glomerular basement membrane via integrin interactions that support the capillary wall to withstand the pulsating filtration pressure. Podocyte structure is maintained by a dynamic actin cytoskeleton. Terminal differentiation is coupled with permanent exit from the cell cycle and arrest in a...

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Share to Chronic Kidney Disease and Diabetes
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Identifiers

PMID: 24007883
DOI: 10.1016/j.ajpath.2013.06.033

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