Article

Zebrafish <i>mbnl</i> mutants model physical and molecular phenotypes of myotonic dystrophy

2019-06-08

Abstract excerpt

The muscleblind RNA binding proteins (MBNL1, MBNL2, and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely responsible for the phenotypes of the human genetic disorder myotonic dystrophy (DM). We generated the first stable zebrafish ( Danio rerio ) models of DM-associated...

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Literature Corpus work: 32ccee3a-ee2b-5c95-aea4-fd5832657044
DOI: 10.1101/665380

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