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Article

The evolution and mutational robustness of chromatin accessibility in Drosophila.

Genome biology - 16 Oct 2023

Khodursky Samuel, Zheng Eric B, Svetec Nicolas, Durkin Sylvia M, Benjamin Sigi, Gadau Alice, Wu Xia, Zhao Li

Abstract excerpt

BACKGROUND: The evolution of genomic regulatory regions plays a critical role in shaping the diversity of life. While this process is primarily sequence-dependent, the enormous complexity of biological systems complicates the understanding of the factors underlying regulation and its evolution. Here, we apply deep neural networks as a tool to investigate the sequence determinants underlying chromatin...

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Identifiers

PMID: 37845780
DOI: 10.1186/s13059-023-03079-5
PMCID: PMC10578003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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