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Article

Improvement of the fibrinolytic activity, acid resistance and thermostability of nattokinase by surface charge engineering.

International journal of biological macromolecules - 31 Dec 2023

Li Yuan, Tang Xiyu, Chen Liangqi, Ma Aixia, Zhu Wenhui, Huang Weidong, Li Jinyao

Abstract excerpt

Nattokinase is a promising thrombolytic drug due to its powerful fibrinolytic effect and few side effects. However, the low fibrinolytic activity and stability of nattokinase have limited its industrial production and oral application. In this study, the basic and neutral amino acid residues on the surface of recombinant nattokinase AprY from Bacillus mojavensis LY-06 (rAprY) were mutated to acidic amino acid...

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PMID: 37839602
DOI: 10.1016/j.ijbiomac.2023.127373

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