Designing a less immunogenic nattokinase from Bacillus subtilis subsp. natto: a computational mutagenesis.

doi:10.1007/s00894-019-4225-y

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Article

Designing a less immunogenic nattokinase from Bacillus subtilis subsp. natto: a computational mutagenesis.

Journal of molecular modeling - 9 Nov 2019

Vianney Yoanes Maria, Tjoa Stanley Evander Emeltan, Aditama Reza, Dwi Putra Sulisyto Emantoko

Abstract excerpt

Nattokinase is an enzyme produced by Bacillus subtilis subsp. natto that contains strong fibrinolytic activity. It has potential to treat cardiovascular diseases. In silico analysis revealed that nattokinase is considered as an antigen, thus hindering its application for injectable therapeutic protein. Various web servers were used to predict B-cell epitopes of nattokinase both continuously and discontinuously to...

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PMID: 31705312
DOI: 10.1007/s00894-019-4225-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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