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SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1

12 Oct 2023

Abstract excerpt

Breast cancer stem cells are mainly responsible for poor prognosis, especially in triple-negative breast cancer (TNBC). In a previous study, we demonstrated that ε-Sarcoglycan (SGCE), a type Ⅰ single-transmembrane protein, is a potential oncogene that promotes TNBC stemness by stabilizing EGFR. Here, we further found that SGCE depletion reduces breast cancer stem cells, partially through inhibiting the...

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PMID: 37838174
DOI: 10.1016/j.jbc.2023.105351

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