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Article

HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer

16 Dec 2020

Abstract excerpt

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. TNBC is enriched with breast cancer stem cells (BCSCs), which are responsible for cancer initiation, cancer progression and worse prognosis. Our previous study found that HES1 was overexpressed and promoted invasion in TNBC. However, the role of HES1 in modulating BCSC stemness of TNBC remains unclear. Here, we found that HES1...

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PMID: 33390847
DOI: 10.7150/ijbs.53477

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