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Article

Lymphedema-Associated Fibroblasts Are Related to Fibrosis and Stage Progression in Patients and a Murine Microsurgical Model

13 Oct 2023

Abstract excerpt

BACKGROUND: The driver of secondary lymphedema (SL) progression is chronic inflammation, which promotes fibrosis. Despite advances in preclinical research, a specific effector cell subpopulation as a biomarker for therapy response or stage progression is still missing for SL. METHODS: Whole skin samples of 35 murine subjects of a microsurgically induced SL model and 12 patients with SL were collected and their...

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PMID: 37832143
DOI: 10.1097/prs.0000000000011141

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