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Article

Increased presynaptic excitability in a migraine with aura mutation.

Brain : a journal of neurology - 1 Feb 2024

Suryavanshi Pratyush, Sawant-Pokam Punam, Clair Sarah, Brennan K C

Abstract excerpt

Migraine is a common and disabling neurological disorder. The headache and sensory amplifications of migraine are attributed to hyperexcitable sensory circuits, but a detailed understanding remains elusive. A mutation in casein kinase 1 delta (CK1δ) was identified in non-hemiplegic familial migraine with aura and advanced sleep phase syndrome. Mice carrying the CK1δT44A mutation were more susceptible to spreading...

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Identifiers

PMID: 37831655
DOI: 10.1093/brain/awad326
PMCID: PMC10834252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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