Article
Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses.
The Journal of experimental medicine - 3 May 2021
VanBlargan Laura A, Errico John M, Kafai Natasha M, Burgomaster Katherine E, Jethva Prashant N, Broeckel Rebecca M, Meade-White Kimberly, Nelson Christopher A, Himansu Sunny, Wang David, Handley Scott A, Gross Michael L, Best Sonja M, Pierson Theodore C, Fremont Daved H, Diamond Michael S
Abstract excerpt
Although Powassan virus (POWV) is an emerging tick-transmitted flavivirus that causes severe or fatal neuroinvasive disease in humans, medical countermeasures have not yet been developed. Here, we developed a panel of neutralizing anti-POWV mAbs recognizing six distinct antigenic sites. The most potent of these mAbs bind sites within domain II or III of the envelope (E) protein and inhibit postattachment viral...
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