Article
Reverse Genetics System for a Human Group A Rotavirus.
Journal of virology - 6 Jan 2020
Kawagishi Takahiro, Nurdin Jeffery A, Onishi Misa, Nouda Ryotaro, Kanai Yuta, Tajima Takeshi, Ushijima Hiroshi, Kobayashi Takeshi
Abstract excerpt
Group A rotavirus (RV) is a major cause of acute gastroenteritis in infants and young children worldwide. Recently, we established an entirely plasmid-based reverse genetics system for simian RV strain SA11. Although that system was robust enough to generate reassortant RVs, including human RV gene segments, and enabled better understanding of the biological differences between animal and human RV strains, a...
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