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Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels

9 Oct 2023

Abstract excerpt

) to diffuse across a hydrophobic cell membrane. These unique voltage-gated cation channels detect changes in membrane potential and, upon activation, help to return the depolarized cell to a resting state during the repolarization stage of each action potential. The Kv3 family of potassium channels is characterized by a high activation potential and rapid kinetics, which play a crucial role for the fast-spiking...

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PMID: 37812700
DOI: 10.1073/pnas.2220029120

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