Article
Genetic variation of staphylococcal LukAB toxin determines receptor tropism.
Nature microbiology - 1 Jun 2021
Perelman Sofya S, James David B A, Boguslawski Kristina M, Nelson Chase W, Ilmain Juliana K, Zwack Erin E, Prescott Rachel A, Mohamed Adil, Tam Kayan, Chan Rita, Narechania Apurva, Pawline Miranda B, Vozhilla Nikollaq, Moustafa Ahmed M, Kim Sang Y, Dittmann Meike, Ekiert Damian C, Bhabha Gira, Shopsin Bo, Planet Paul J, Koralov Sergei B, Torres Victor J
Abstract excerpt
Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence factors. Whether these alterations affect functionality is poorly understood. Here, we studied the highly polymorphic pore-forming toxin LukAB. We discovered that the LukAB toxin variants produced by S. aureus CC30 and CC45 kill human phagocytes regardless...
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