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Article

Human immunodeficiency virus 1 5'-leader mutations in plasma viruses before and after the development of reverse transcriptase inhibitor-resistance mutations.

The Journal of general virology - 1 Oct 2023

Nouhin Janin, Tzou Philip Lei, Rhee Soo-Yon, Sahoo Malaya K, Pinsky Benjamin A, Krupkin Miri, Puglisi Joseph D, Puglisi Elisabetta V, Shafer Robert W

Abstract excerpt

Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT) initiation depends on interaction between viral 5'-leader RNA, RT and host tRNA3Lys. Therefore, we sought to identify co-evolutionary changes between the 5'-leader and RT in viruses developing RT-inhibitor resistance mutations. We sequenced 5'-leader positions 37-356 of paired plasma virus samples from 29 individuals developing the nucleoside RT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37801004
DOI: 10.1099/jgv.0.001898
PMCID: PMC10721937

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