Article
Long-Read Sequencing with Hierarchical Clustering for Antiretroviral Resistance Profiling of Mixed Human Immunodeficiency Virus Quasispecies.
Clinical chemistry - 3 Oct 2023
Ng Timothy Ting-Leung, Su Junhao, Lao Hiu-Yin, Lui Wui-Wang, Chan Chloe Toi-Mei, Leung Amy Wing-Sze, Jim Stephanie Hoi-Ching, Lee Lam-Kwong, Shehzad Sheeba, Tam Kingsley King-Gee, Leung Kenneth Siu-Sing, Tang Forrest, Yam Wing-Cheong, Luo Ruibang, Siu Gilman Kit-Hang
Abstract excerpt
BACKGROUND: HIV infections often develop drug resistance mutations (DRMs), which can increase the risk of virological failure. However, it has been difficult to determine if minor mutations occur in the same genome or in different virions using Sanger sequencing and short-read sequencing methods. Oxford Nanopore Technologies (ONT) sequencing may improve antiretroviral resistance profiling by allowing for...
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