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The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

6 Oct 2023

Abstract excerpt

ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and PrrF2 small RNAs (sRNAs), which post-transcriptionally repress expression of nonessential iron-containing proteins, thus sparing this nutrient for more critical...

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PMID: 37800921
DOI: 10.1128/msphere.00392-23

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