Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer.

doi:10.1007/s10654-023-01048-7

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Article

Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer.

European journal of epidemiology - 1 Oct 2023

Wichert Katharina, Hoppe Reiner, Ickstadt Katja, Behrens Thomas, Winter Stefan, Herold Robert, Terschüren Claudia, Lo Wing-Yee, Guénel Pascal, Truong Thérèse, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Lush Michael, Andrulis Irene L, Brenner Hermann, Chang-Claude Jenny, Cox Angela, Cross Simon S, Czene Kamila, Eriksson Mikael, Figueroa Jonine D, García-Closas Montserrat, Goldberg Mark S, Hamann Ute, He Wei, Holleczek Bernd, Hopper John L, Jakubowska Anna, Ko Yon-Dschun, Lubiński Jan, Mulligan Anna Marie, Obi Nadia, Rhenius Valerie, Shah Mitul, Shu Xiao-Ou, Simard Jacques, Southey Melissa C, Zheng Wei, Dunning Alison M, Pharoah Paul D P, Hall Per, Easton Douglas F, Brüning Thomas, Brauch Hiltrud, Harth Volker, Rabstein Sylvia

Abstract excerpt

Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study...

Topics

Humans
Female
Breast Neoplasms
Melatonin
Bayes Theorem
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Case-Control Studies

Genetic Predisposition to Disease

Source

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Identifiers

PMID: 37789226
DOI: 10.1007/s10654-023-01048-7
PMCID: PMC10570222

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