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Article

A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies.

The Journal of infectious diseases - 15 May 2024

Atmar Robert L, Ettayebi Khalil, Ramani Sasirekha, Neill Frederick H, Lindesmith Lisa, Baric Ralph S, Brinkman Amanda, Braun Ralph, Sherwood James, Estes Mary K

Abstract excerpt

A GII.2 outbreak in an efficacy study of a bivalent virus-like particle norovirus vaccine, TAK-214, in healthy US adults provided an opportunity to examine GII.4 homotypic vs GII.2 heterotypic responses to vaccination and infection. Three serologic assays-virus-like particle binding, histoblood group antigen blocking, and neutralizing-were performed for each genotype. Results were highly correlated within a...

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Identifiers

PMID: 37781879
DOI: 10.1093/infdis/jiad401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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