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Sulforaphane Mitigates High‐Fat Diet‐Induced Obesity by Enhancing Mitochondrial Biogenesis in Skeletal Muscle via the HDAC8‐PGC1α Axis

29 Sept 2023

Abstract excerpt

Scope Histone deacetylases (HDACs) play a crucial role in the transcriptional regulation of various genes which can contribute to metabolic disorders. Although sulforaphane (SFN), a natural HDAC inhibitor, has been reported to alleviate obesity in humans and mice, the specific mechanisms and how HDACs contribute to SFN's anti‐obesity effects remain unclear. Methods and results Oral administration of SFN in mice...

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PMID: 37775334
DOI: 10.1002/mnfr.202300149

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