Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

doi:10.1016/j.celrep.2016.08.005

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Article

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

Cell reports - 13 Sept 2016

Gaur Vidhi, Connor Timothy, Sanigorski Andrew, Martin Sheree D, Bruce Clinton R, Henstridge Darren C, Bond Simon T, McEwen Kevin A, Kerr-Bayles Lyndal, Ashton Trent D, Fleming Cassandra, Wu Min, Pike Winer Lisa S, Chen Denise, Hudson Gregg M, Schwabe John W R, Baar Keith, Febbraio Mark A, Gregorevic Paul, Pfeffer Frederick M, Walder Ken R, Hargreaves Mark, McGee Sean L

Abstract excerpt

Drugs that recapitulate aspects of the exercise adaptive response have the potential to provide better treatment for diseases associated with physical inactivity. We previously observed reduced skeletal muscle class IIa HDAC (histone deacetylase) transcriptional repressive activity during exercise. Here, we find that exercise-like adaptations are induced by skeletal muscle expression of class IIa HDAC mutants...

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PMID: 27626651
DOI: 10.1016/j.celrep.2016.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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